Yes, definitely do your research and work up carefully if/when you start experimenting with smokeless...
Ever try Hodgdons Triple 7?? It is a direct black powder equivalent (like Pyrodex, only much cleaner burning) and I use it in my old Thompson Center Renegade black powder rifle. It is an "old school" side , octagon barrel type. In-lines were still a year of 2 from coming out when I bought it. I cannot use the pellets like the modern in-lines do because of my sideways ignition. I switched to Triple 7 because the old Goex FFG is getting harder to source around here thanks to stiffer regs on black powder vs smokeless causing many dealers to just let it go.
I have had a few hiccups with the Triple 7, mainly poor ignition.. I switched to Winchester magnum no.11 caps and that helped alot. I plan to convert to a shotgun primer setup to insure the most reliable ignition possible. Other than that, it performs the same as old Goex and burns MUCH cleaner....
Might be worth a try in your 50-110??? With due diligence in caution and research of course...
My standard hunting load in my muzzle loader is 100gr Triple 7 (same charge I used with FFG) pushing a 375gr Hornady Maxi Hunter bullet. Pretty close to what you are doing with your 50-110 if you are using similar weight bullets. But I wonder, does the fact you are using a metallic cartridge as opposed to my muzzle loader change any rules of the game for you????